The 20-year-old Frenchwoman will represent the team in F1 Academy, the all-female racing series, with the support of Prema Racing.
Doriane has confirmed herself as one of the foremost female racing drivers in recent years, impressing as rose through the ranks of endurance racing.
The Parisian is a member of the ground-breaking Iron Dames project, the pioneering platform committed to promoting and supporting women in motorsport.
“I am incredibly happy to join the Mercedes Junior Programme and to represent the team in F1 Academy this year with Prema Racing,” she said.
“A new chapter begins, and I am proud to make this next step in such a prestigious team and with the Iron Dames project.
“I am grateful for their trust and honoured to race for their colours.
“Moving into single-seaters was a clear objective for my career, and to be in this environment is a great approach. I am working very hard to reach the top level of this sport and I cannot wait to go racing.”